University Degrees :
Bachelor of Science (Hons I) University of New South Wales (1984)
Ph.D (Faculty of Medicine) University of Sydney (1990)
Awards and distinctions:
1984 Bachelor of Science, First Class Honours (Biochemistry), UNSW, Sydney.
1986-1990 University of Sydney Post-graduate Research Scholarship.
1991 NSW Cancer Council Travelling Scholarship.
1991-1992 University of Sydney Medical Foundation Research Fellowship.
1994 ISREC (Lausanne) Travel Scholarship.
1997 -1999 University of Sydney (Faculty of Medicine) Rolf Edgar Lake Research Fellowship.
2003-2012 NH&MRC Senior Research Fellowship.
2005 WMI Science Prize (institutional recognition of achievement)
2009- Editorial board of two international Journals
2012- Appointed Associate Professor (Medicine, University of Sydney)
1984 : Department of Biochemistry, University of NSW Honours (Supervisor, Dr. Tom Stewart)
1985 : Department of Physiology, University of Sydney, Research Assistant
1986-1990 : PhD: Department of Medical Oncology, University of Sydney, Westmead Centre
(Supervisor, Professor Richard Kefford) and CSIRO Laboratory for Molecular Biology, North Ryde (Co-supervisor, Dr. Merilyn Sleigh)
1990-1991 : Department of Medical Oncology, Westmead Hospital, Sydney Research Fellow
1992-1994 : Post-doctoral studies: Genetics Unit, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland: Supervisor, Dr. Lukas Kühn
1995-1996 : Post-doctoral studies: MRC Laboratory of Molecular Biology, Cambridge UK: Advisors, Dr’s. Jonathon Karn and Mike Gait (Editors of J. Mol. Biol and Nuc. Acids Res.)
1997 -: Group leader: Westmead Institute for Cancer Research, Westmead Millennium Institute, Sydney
Rolf Edgar Lake Research Fellow (University of Sydney, Faculty of Medicine) 1997-1999
NHMRC Research Fellow (University of Sydney) 2000-2002
2003-2012 : NHMRC Senior Research Fellow
2013-2015: CINSW Senior Research Fellow (University of Sydney)
Research staff and aims
From 1999-2015 my research team comprised up to 10 full-time staff and students each year. We studied cell biology of cancer with special focus on protein trafficking and subcellular localisation of proteins.
National and International Profile
Selected Speaker Invitations at Conferences (2001-)
2001 : Regulation of the tumour suppressor APC by nuclear export.
13th Annual Lorne Cancer Conference, Lorne, Victoria
2001 : Nuclear export of tumor suppressor proteins.
2nd Airlie Nuclear Transport Conference, Airlie, Virginia, USA
2002 : Regulation of beta-catenin in cancer.
Sydney Transcription Group Meeting, Sydney
2003 : Regulation of BRCA1/BARD1 in breast cancer
15th Annual Lorne Cancer Conference, Lorne, Victoria
2003: The ins and outs of APC and beta-catenin nuclear transport
1st EMT international cell biology meeting, Port Douglas QLD
2004 : Regulation of APC intracellular trafficking
2nd Australian Health and Medical Reseach Congress, Sydney
2005: Regulation of BRCA1 and BARD1
ComBio Conference, Adelaide
2006: Regulation of APC and beta-catenin subcellular localization.
Cellular signalling and protein networking minisymposium, Yonsei University, Seoul, South Korea.
2008: BRCA1 redistribution in response to DNA damage.
4th Australian Health and Medical Reseach Congress, Brisbane
2008: Regulation of cancer proteins APC and BRCA1
University of Sydney Cancer Research Network meeting
2010 : Regulation of BRCA1 in breast cancer. (Invited speaker and Session Chair)
2nd BIT breast cancer conference, Shanghai China
2010: Regulation of APC transport in cancer.
Protein trafficking session, Ozbio 2010, Melbourne
2010: Regulation of BRCA1 dynamics and breast cancer.
3rd China-University of Sydney Symposium and University Expo, Shanghai China
2012: Regulation of APC intracellular trafficking in cancer.
Protein transport session , Ozbio 2012, Adelaide
2014 : Regulation of APC and beta-catenin proteins in cancer.
EMBO International Wnt signaling workshop and conference , Cable Beach Broome, WA
Invited Seminars at International Institutes (2007-)
2007: Regulation and novel functions of APC in cancer.
Host: Dr. Inke Nathke, Institute of Cell and Developmental Biology, University of Dundee
2007: Regulation of BARD1 in cancer
(Host: Dr. Joanna Morris and Prof. Ellen Solomon, Guys Hospital London)
2011 : Regulation of BRCA1 in cancer.
Host: Dr Josean Rodriguez, School of Genetics, University of Bilbao, Spain
2011 : Intracellular transport and function of BRCA1 and BARD1.
Host: Prof. Lukas Kuhn, ISREC at EPFL, Lausanne, Switzerland
Invited Panel Chair at conference
2002: Nuclear Transport Session
University of Sydney College of Health Sciences Medical Research Conference, Leura, NSW
2005: Session: Nuclear transport, development and disease
Mechanisms of Nuclear Transport Symposium, Brisbane
2010 : Targeting DNA repair and synthesis
2nd BIT breast cancer conference, Shanghai China
2012: Cancer protein regulation session
2012 Sydney Cancer Conference
Organisation and Chair of conferences
2002: 6th Annual NSW Cell and Developmental Biology Meeting, Westmead Millennium Institute, Sydney (approximately 120 participants)
2009: WMI Cancer Cell Biology workshop, Westmead Millennium Institute, Sydney
2011: Member of Organising committee for 2012 Sydney Cancer Conference, Univ Sydney
2013-14: Member Organising committee for 2014 EMBO Wnt signaling conference, Broome WA
Membership of Learned Societies (1992-)
1992-1995 Member of Swiss Societies for Experimental Biology (USGEB)
1996-1997 Member of Cambridge RNA Interest Group
1998- Member of Sydney Protein Group
2001- Member of Australian Society for Medical Research
2003- Member National Association of Research Fellows (NARF)
2004- Member of the International EMT society (TEMTIA)
2005- NSW Public Officer for TEMTIA
2006- University of Sydney Cancer Research Network
Peer Review activities (2008-)
Invited Member of National Grant Review Panels (GRPs):
2008-2010 Member of NHMRC Grant Review Panel for Career Development Awards
2010 Member of NHMRC Grant Review Panel for Cell Biology
2011 Member of priority-driven cancer research grants (PDCRG) review committee
2012 Member of National Breast Cancer Foundation Translational Grants review committee
2013- Member, University of Sydney Early Career Researcher grants (Faculty of Medicine)
Member, NBCF Concept grant review panel
Member, NHMRC Grants Review Panel (cell biology)
Invited Member of National Experts Panels:
2008 Invited member of Expert Panel, Colon Cancer Review and Policy workshop, Darlinghurst (The Cancer Council NSW)
Invited Member of International Editorial Boards:
2009-2015 Biomed Research International
2009-2014 Open Breast Cancer Journal
2009-2013 World Journal of Biological Chemistry
Chair of WMI Committees or Facilities (up to 2015)
2006- Established the WMI Cell Imaging Facility (with current Zeiss Axiovert and Deltavision live cell microscopy systems, Nuance multispectral imaging system and Olympus FV1000 confocal system all were relocated into new WMI building cell imaging core facility in 2014)
2006- Chair of WMI cell imaging facility committee
2012- Chair of WMI Grant Mentoring Application committee
Member of University of Sydney Committees
2008- University of Sydney NHMRC grant strategists committee
2008- Member of University of Sydney Mentoring program
2010 Invited member of USyd Faculty of Medicine-China delegation to Shanghai
2010 Invited participant in University of Sydney School of Medicine Strategic Planning Workshop, Darlington Centre 20July2010
2012 Organising committee for Sydney Cancer Conference at Univ. Sydney
Teaching and learning
2000-2015 Supervision of eight USyd PhD students and one MSc (Netherlands) student
2005-2010 Supervision of three USyd Pharmacology Honours students to completion
2005-2013 Marking and assessment of honours students for Department of Pharmacology (USyd).
External Research Grant Funding
Total competitive funding from >25 successful research grants (eg. NHMRC, ARC and Cancer Council NSW): (> $8 million since 2000)
Community and Media (from 2005 only; 9 others including national adverts prior)
1. 2005 Cancer Council NSW (CCNSW) : Photo and report in brochure, awards reception.
2. 2005 CCNSW : Speech for fundraising to donors at Eden Gardens, Sydney.
3. 2005 CCNSW: Speech for fundraising at Cancer Council building, Sydney
4. 2007 Blacktown Rotary Club: Public lecture at Westmead
5. 2012 CCNSW: Interview for advertising campaign – national TV and theatres
6. 2012 WMI cancer story: (smiley cell image) Media interviews for international newspaper and websites (eg. Channel 9, SBS) and Youtube (>32,000 hits)
7. 2012 CCNSW Keynote address: Blacktown relay for life event
8. 2014 Cancer Council Australia: Photoshoot and national exposure for Daffodil Day campaign
9. 2014 National Breast Cancer Foundation: Speech at Pink ribbon event Gymea Tradies
10. 2014 Westmead Hospital Education Week: “The Great Debate”
Total of 96 publications with many in the top-ranking journals of the field: Nature Cell Biology – sole author article (1), Molecular Biology of the Cell (1), J. Cell Science (1), Journal of Biological Chemistry (19), EMBO Journal (1), EMBO Reports (2), Traffic (3), Cellular Signalling (8), Cancer Research (2) and Oncogene (2).